Pathways of memory CD8+ T-cell development
نویسندگان
چکیده
منابع مشابه
Discriminating between different pathways of memory CD8+ T cell differentiation.
Despite the rapid accumulation of quantitative data on the dynamics of CD8(+) T cell responses following acute viral or bacterial infections of mice, the pathways of differentiation of naive CD8(+) T cells into memory during an immune response remain controversial. Currently, three models have been proposed. In the "stem cell-associated differentiation" model, following activation, naive T cell...
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CD8 T cells are a key component of the host adaptive immune responses that helps to eradicate invading virus and other cell-associated pathogens. The CD8 T cell responses to an acute infection consist of three well defined phases: naïve pathogen-specific T cells (CD8N) become activated and expand resulting in large numbers of effector cells (CD8E); the contraction of these CD8E into memory cell...
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Memory CD8 T cells generated after acute viral infections or live vaccines can persist for extended periods, in some instances for life, and play an important role in protective immunity. This long-lived immunity is achieved in part through cytokine-mediated homeostatic proliferation of memory T cells while maintaining the acquired capacity for rapid recall of effector cytokines and cytolytic m...
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Progression of spontaneous autoimmune diabetes is associated with development of a disease-countering negative-feedback regulatory loop that involves differentiation of low-avidity autoreactive CD8(+) cells into memory-like autoregulatory T cells. Such T cells blunt diabetes progression by suppressing the presentation of both cognate and noncognate Ags to pathogenic high-avidity autoreactive CD...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2009
ISSN: 0014-2980
DOI: 10.1002/eji.200939555